Yuki Itose is a hearing-impaired university student whose world has been shrouded with silence since birth. She has lived in the same place her whole life, and rarely interacts with others save for her best friend, Rin Fujishiro. During her commute one day, she meets the silver-haired and multilingual Itsuomi Nagi, a mutual friend of Rin. Unlike most, Itsuomi is unwavering when he learns of Yuki's impairment; this, along with his experiences abroad, fascinates and touches her. After they part, her fondness of him starts to grow. A new world begins to open for both Yuki and Itsuomi as they learn about each other's different lives.

Yubisaki to Renren is a lighthearted, romantic comedy that illustrates the silent life of a university student and how one man sharing his world starts to change her own.