The manga revolves around the Sakura household, which has since ancient times worked as sake brewers. One day the daughter of the household finds a katana in her family's warehouse and when she unsheathes it, the sword starts to shine. The title Sakura Juuyuushi is a play on words of Sanada Juuyuushi, a story of the group of 10 ninja who assisted the warlord Sanada Yukimura during the Warring States era of Japan.