Ryousuke Akiba calls himself ES, a code name taken from a mysterious scientific experiment. Ryousuke will live to be at least two centuries old and possesses strange mental powers: He can enter people's minds, discover their darkest secrets, even rearrange their memories so that complete strangers will treat him like family. Ryousuke acts not out of malice but for survival—wandering Tokyo for reasons known only to him. No one recognizes him for what he is...until Dr. Mine Kujyou, a determined researcher, meets someone who challenges everything she knows about science—ES, possessor of the Eternal Sabbath gene. But is he the only one?