In a certain food container factory, suggestive rumors about Mako Higari say that she will sleep with anybody. Her coworker Kinoshita believes this, so testing his luck, he strikes up a conversation with Mako, and the two eventually end up in a hotel room.

Soon, the pair are ready to have sexual intercourse. However, the night quickly does not go as planned—while engaged in the act, a stream of blood suddenly gushes out of Mako's nose! Mako explains this frequently occurs whenever she comes into physical contact with anything impure. Finding it unsettling, Kinoshita runs away and leaves Mako back at square one.

Botabota follows Mako's journey toward obtaining a normal life where all her unfulfilled desires are achieved—which proves difficult when everyone and everything she touches is filthy one way or another.

Included one-shot: Shirohige to Boin (White Beard and Boobs)