Every 50 years, a battle royale between multiple clans commences in order to achieve the head title "Family Guy" and become the ruling head of all the sorcerer clans. Each clan chooses their own specific representative of their clans, each gambling his or her own life for the title. The only difference is compared to the previous wars, the battlefield takes place within Quahog City, the ground zero for the Ghetto Rays incident.

Bloodedge the Griffin, and agent of Shinra, a special unit directly affiliated with the government and created to deal with supernatural phenomena, monsters, and such is tasked to investigated the Ghetto Rays infested area not knowing of the violent war that is about to approach him.