The year is 2013 in the fictional city of Chutowan (ちゅとわん) located in Japan. After a series of unfortunate events, 23 y/o Yoh Yomi ends up living as a hikikomori (japanese term to describe reclusive adolescents or adults who withdraw from society and seek extreme degrees of isolation), being sustained by his wealthy parents with the promise of finishing his education at college.

After receiving the news of their parents getting hospitalized, Yeri Yomi, Yoh's sister, a successful psychologist and stand user, goes to inform his brother that he may lose his source of income due to the possibility of their parents dying, but after getting to him, she discovers that his brother has been living as a hikikomori for 4 years. To help him, she starts treating him in the mental health hospital where she works.

Follow Yoh in his recovery journey to try to fit in Japan's competitive society alongside other patients of the Mental Health Hospital while mystery regarding stand users happens in the background.